Multisite Study of Cryptosporidiosis in Children with Diarrhea in India

被引：63

作者：

Ajjampur, Sitara Swarna Rao ^{[1
]}

Liakath, Farzana Begum ^{[1
]}

Kannan, Arun ^{[1
]}

Rajendran, Priya ^{[1
]}

Sarkar, Rajiv ^{[1
]}

Moses, Prabhakar Devarajan ^{[1
]}

Simon, Anna ^{[1
]}

Agarwal, Indira ^{[1
]}

Mathew, Ann ^{[2
]}

O'Connor, Roberta ^{[3
]}

Ward, Honorine ^{[3
]}

Kang, Gagandeep ^{[1
]}

机构：

[1] Christian Med Coll & Hosp, Dept Gastrointestinal Sci, Vellore 632004, Tamil Nadu, India

[2] St Stephens Hosp, New Delhi, India

[3] Tufts Med Ctr, Boston, MA USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2010年 / 48卷 / 06期

关键词：

PHYLOGENETIC ANALYSIS; SOUTH-INDIA; SEASONALITY; EPIDEMIOLOGY; HOMINIS; PARVUM; IDENTIFICATION; INFECTIONS; LIKELIHOOD; PARASITES;

D O I：

10.1128/JCM.02509-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cryptosporidium spp., a common cause of diarrhea in children, were investigated in the first multisite study in India. Diarrheal stools from hospitalized children aged <5 years from Delhi, Trichy, and Vellore were analyzed by microscopy, PCR-restriction fragment length polymorphism (RFLP), and/or sequencing at the small-subunit (SSU) rRNA and Cpgp40/15 loci for species determination and subgenotyping, respectively. Seventy of 2,579 (2.7%) children, 75% of whom were <2 years old, had cryptosporidial diarrhea as determined by microscopy. Genotyping and subgenotyping showed that Cryptosporidium hominis was the most commonly identified species (59/67 children), and subgenotypes Ie, Ia, Ib, and Id were common in all centers. A novel C. parvum subgenotype, IIn, was identified in Vellore. Meteorological analysis revealed a higher rate of cryptosporidial positivity during hotter and drier weather in Delhi.

引用

页码：2075 / 2081

页数：7

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