Biocompatible and Highly Sensitive Nitric Oxide Sensor Particles Prepared by Layer-by-layer Assembly

被引：13

作者：

Amemori, Suzuka ^{[1
]}

Matsusaki, Michiya ^{[1
,2
]}

Akashi, Mitsuru ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

[2] Japan Sci & Technol Agcy JST, Tokyo, Japan

来源：

CHEMISTRY LETTERS | 2010年 / 39卷 / 01期

关键词：

CELLS; DIAMINOFLUORESCEINS; INDICATORS; PH;

D O I：

10.1246/cl.2010.42

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Biocompatible sensor particles with high nitric oxide (NO) sensitivity were fabricated by a combination of layer-by-layer assembly and acid-free chitosan dissolving techniques. The sensor particles encapsulating 4,5-diaminofluorescein (DAF-2), an NO fluorescent probe, can detect 5-500 nM NO and had higher cytocompatibility as compared to DAF-2 molecules. These sensor particles will be useful for quantitative and spatial analyses of extracellular NO molecules from living cells.

引用

页码：42 / 43

页数：2

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