Free radicals in cell biology

被引:202
作者
Djordjevic, VB [1 ]
机构
[1] Univ Nis, Fac Med, Inst Biochem, Nish, Serbia
来源
INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL. 237 | 2004年 / 237卷
关键词
reactive oxygen species; antioxidant enzymes; NADPH oxidase; xanthine oxidase; nitric oxide; atherosclerosis; inflammatory;
D O I
10.1016/S0074-7696(04)37002-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In aerobic cells, free radicals are constantly produced mostly as reactive oxygen species. Once produced, free radicals are removed by antioxidant defenses including enzyme catalase, glutathione peroxidase, and superoxide dismutase. Reactive oxygen species, including nitric oxide and related species, commonly exert a series of useful physiological effects. However, imbalance between prooxidant and antioxidant defenses in favor of prooxiclants results in oxidative stress associated with the oxidative modification of biomolecules such as lipids, proteins, and nucleic acids. Alone or in combination with primary ethiological factors, free radicals are involved in a pathogenesis of more than a hundred diseases. This chapter reviews the basic science of some of the potential sources and characteristics of free radicals, as well as antioxidant enzymes. Special attention is paid to the role of free radicals in the pathogenesis of atherosclerosis and immunology-mediated inflammatory reaction.
引用
收藏
页码:57 / 89
页数:33
相关论文
共 137 条
  • [21] SIGNAL-INDUCED SITE-SPECIFIC PHOSPHORYLATION TARGETS I-KAPPA-B-ALPHA TO THE UBIQUITIN-PROTEASOME PATHWAY
    CHEN, ZJ
    HAGLER, J
    PALOMBELLA, VJ
    MELANDRI, F
    SCHERER, D
    BALLARD, D
    MANIATIS, T
    [J]. GENES & DEVELOPMENT, 1995, 9 (13) : 1586 - 1597
  • [22] PURIFICATION AND PROPERTIES OF RAT LUNG SOLUBLE GLUTATHIONE PEROXIDASE
    CHIU, DTY
    STULTS, FH
    TAPPEL, AL
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 445 (03) : 558 - 566
  • [23] COPPER, ZINC SUPEROXIDE-DISMUTASE IS PRIMARILY A CYTOSOLIC PROTEIN IN HUMAN-CELLS
    CRAPO, JD
    OURY, T
    RABOUILLE, C
    SLOT, JW
    CHANG, LY
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10405 - 10409
  • [24] Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase
    Dana, R
    Leto, TL
    Malech, HL
    Levy, R
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (01) : 441 - 445
  • [25] Biomarkers of free radical damage applications in experimental animals and in humans
    De Zwart, LL
    Meerman, JHN
    Commandeur, JNM
    Vermeulen, NPE
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1999, 26 (1-2) : 202 - 226
  • [26] Assembly of the phagocyte NADPH oxidase: Molecular interaction of oxidase proteins
    DeLeo, FR
    Quinn, MT
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1996, 60 (06) : 677 - 691
  • [27] DJORDJEVIC BV, 1998, J ENVIRON PATHOL TOX, V17, P277
  • [28] Does captopril change oxidative stress in puromycin aminonucleoside nephropathy?
    Djordjevic, VB
    Cosic, V
    Pavlovic, D
    Vlahovic, P
    Jevtovic, T
    Kocic, G
    Savic, V
    [J]. RENAL FAILURE, 2000, 22 (05) : 535 - 544
  • [29] Phagocyte NADPH oxidase p67-phox possesses a novel carboxylterminal binding site for the GTPases Rac2 and Cdc42
    Faris, SL
    Rinckel, LA
    Huang, J
    Hong, YR
    Kleinberg, ME
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 247 (02) : 271 - 276
  • [30] THE ROLE OF 8-HYDROXYGUANINE IN CARCINOGENESIS
    FLOYD, RA
    [J]. CARCINOGENESIS, 1990, 11 (09) : 1447 - 1450