Genomics of oral bacteria

被引：30

作者：

Duncan, MJ ^{[1
]}

机构：

[1] Forsyth Inst, Dept Mol Genet, Boston, MA 02115 USA

来源：

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE | 2003年 / 14卷 / 03期

关键词：

genomics of oral bacteria;

D O I：

10.1177/154411130301400303

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Advances in bacterial genetics came with the discovery of the genetic code, followed by the development of recombinant DNA technologies. Now the field is undergoing a new revolution because of investigators' ability to sequence and assemble complete bacterial genomes. Over 200 genome projects have been completed or are in progress, and the oral microbiology research community has benefited through projects for oral bacteria and their non-oral-pathogen relatives. This review describes features of several oral bacterial genomes, and emphasizes the themes of species relationships, comparative genomics, and lateral gene transfer. Genomics is having a broad impact on basic research in microbial pathogenesis, and will lead to new approaches in clinical research and therapeutics. The oral microbiota is a unique community especially suited for new challenges to sequence the metagenomes of microbial consortia, and the genomes of uncultivable bacteria.

引用

收藏

页码：175 / 187

页数：13

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