Driving ribosome assembly

被引:385
作者
Kressler, Dieter [1 ,2 ]
Hurt, Ed [1 ]
Bassler, Jochen [1 ]
机构
[1] Heidelberg Univ, Zentrum Biochem, D-69120 Heidelberg, Germany
[2] Univ Fribourg, Dept Med, Biochem Unit, CH-1700 Fribourg, Switzerland
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2010年 / 1803卷 / 06期
关键词
Ribosome assembly; Nuclear export of ribosomes; Diamond-Blackfan anemia; Shwachman-Diamond syndrome; Dyskeratosis congenita; Cartilage-hair hypoplasia; Bowen-Conradi syndrome; Cancer; Quality control of ribosomes; DEAD-BOX PROTEINS; GTP-BINDING PROTEIN; RNA-QUALITY-CONTROL; COMPREHENSIVE MUTATIONAL ANALYSIS; DIAMOND-SYNDROME PROTEIN; NUCLEAR EXPORT; PRE-RIBOSOMES; SACCHAROMYCES-CEREVISIAE; SUBUNIT REQUIRES; CYTOPLASMIC MATURATION;
D O I
10.1016/j.bbamcr.2009.10.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ribosome biogenesis is a fundamental process that provides cells with the molecular factories for cellular protein production Accordingly, its misregulation lies at the heart of several hereditary diseases (e.g. Diamond-Blackfan anemia). The process of ribosome assembly comprises the processing and folding of the pre-rRNA and its concomitant assembly with the ribosomal proteins Eukaryonc ribosome biogenesis relies on a large number (>200) of non-ribosomal factors, which confer directionality and accuracy to this process. Many of these non-ribosomal factors fall into different families of energy-consuming enzymes, notably including ATP-dependent RNA helicases, AAA-ATPases. GTPases, and kinases. Ribosome biogenesis is highly conserved within eukaryonc organisms: however, due to the combination of powerful genetic and biochemical methods. it is best studied in the yeast Saccharomyces cerevisiae. This review summarizes our current knowledge on eukaryonc ribosome assembly, with particular focus on the molecular role of the involved energy-consuming enzymes. (C) 2009 Elsevier B V. All rights reserved.
引用
收藏
页码:673 / 683
页数:11
相关论文
共 165 条
[1]   The human DDX and DHX gene families of putative RNA helicases [J].
Abdelhaleem, M ;
Maltais, L ;
Wain, H .
GENOMICS, 2003, 81 (06) :618-622
[2]   Yeast Rio1p is the founding member of a novel subfamily of protein serine kinases involved in the control of cell cycle progression [J].
Angermayr, M ;
Roidl, A ;
Bandlow, W .
MOLECULAR MICROBIOLOGY, 2002, 44 (02) :309-324
[3]   Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing [J].
Ansel, K. Mark ;
Pastor, William A. ;
Rath, Nicola ;
Lapan, Ariya D. ;
Glasmacher, Elke ;
Wolf, Christine ;
Smith, Laura C. ;
Papadopoulou, Nikoletta ;
Lamperti, Edward D. ;
Tahiliani, Mamta ;
Ellwart, Joachim W. ;
Shi, Yujiang ;
Kremmer, Elisabeth ;
Rao, Anjana ;
Heissmeyer, Vigo .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2008, 15 (05) :523-530
[4]   Mutation of a Gene Essential for Ribosome Biogenesis, EMG1, Causes Bowen-Conradi Syndrome [J].
Armistead, Joy ;
Khatkar, Sunita ;
Meyer, Britta ;
Mark, Brian L. ;
Patel, Nehal ;
Coghlan, Gail ;
Lamont, Ryan E. ;
Liu, Shuangbo ;
Wiechert, Jill ;
Cattini, Peter A. ;
Koetter, Peter ;
Wrogemann, Klaus ;
Greenberg, Cheryl R. ;
Entian, Karl-Dieter ;
Zelinski, Teresa ;
Triggs-Raine, Barbara .
AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 84 (06) :728-739
[5]   Identification of a 60S preribosomal particle that is closely linked to nuclear export [J].
Bassler, J ;
Grandi, P ;
Gadal, O ;
Lessmann, T ;
Petfalski, E ;
Tollervey, D ;
Lechner, J ;
Hurt, E .
MOLECULAR CELL, 2001, 8 (03) :517-529
[6]   The NUG1 GTPase reveals an N-terminal RNA-binding domain that is essential for association with 60 S pre-ribosomal particles [J].
Bassler, Jochen ;
Kallas, Martina ;
Hurt, Ed .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (34) :24737-24744
[7]   Phosphorylation of mammalian eukaryotic translation initiation factor 6 and its Saccharomyces cerevisiae homologue Tif6p:: Evidence that phosphorylation of Tif6p regulates its nucleocytoplasmic distribution and is required for yeast cell growth [J].
Basu, U ;
Si, K ;
Deng, HT ;
Maitra, U .
MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (17) :6187-6199
[8]   Characterization of the essential activities of Saccharomyces cerevisiae Mtr4p, a 3′→5′ helicase partner of the nuclear exosome [J].
Bernstein, Jade ;
Patterson, Dimeka N. ;
Wilson, Gerald M. ;
Toth, Eric A. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (08) :4930-4942
[9]   Comprehensive mutational analysis of yeast DEXD/H box RNA helicases involved in large ribosomal subunit biogenesis [J].
Bernstein, KA ;
Granneman, S ;
Lee, AV ;
Manickam, S ;
Baserga, SJ .
MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (04) :1195-1208
[10]   The long unwinding road of RNA helicases [J].
Bleichert, Franziska ;
Baserga, Susan J. .
MOLECULAR CELL, 2007, 27 (03) :339-352