Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels

被引：101

作者：

Geoffroy, K ^{[1
]}

Troncy, L ^{[1
]}

Wiernsperger, N ^{[1
]}

Lagarde, M ^{[1
]}

El Bawab, S ^{[1
]}

机构：

[1] INSERM, INSA Lyon, UMR 585, MERCK Sante,Diabet Microangiopathy Res Unit, F-69621 Villeurbanne, France

来源：

FEBS LETTERS | 2005年 / 579卷 / 05期

关键词：

streptozotocin; glomerular proliferation; mesangial cells; ceramidase; sphingosine kinase; sphingosine-1-phosphate;

D O I：

10.1016/j.febslet.2004.12.094

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, the effects of short-term diabetes (4 days) on rat renal glomerular cells proliferation and the potential involvement of sphingolipids in this process were investigated. Immunohistochemical analysis showed that streptozotocin (STZ)-induced diabetes promoted increased intra-glomerular hyperplasia, particularly marked for mesangial cells. This was associated with a concomitant increase in neutral ceramidase and sphingosine-kinase activities and the accumulation of the pro-proliferative sphingolipid sphingosine-1-phosphate, in glomeruli isolated from kidney cortex of STZ-treated rats. These results suggest a possible involvement of sphingolipid metabolites in the glomerular proliferative response during the early stages of diabetic nephropathy. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1249 / 1254

页数：6

共 23 条

[1] Evidence for the presence of multiple forms of Sph kinase in human platelets [J].