Synthesis of dispacamide from the marine sponge Agelas dispar

被引：46

作者：

Lindel, T ^{[1
]}

Hoffmann, H ^{[1
]}

机构：

[1] Univ Heidelberg, Inst Pharmazeut Chem, D-69120 Heidelberg, Germany

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(97)10387-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The marine natural product dispacamide (1) has been synthesized for the first time starting from 2-thiohydantoin (2). A facile one pot conversion of alkylidene thiohydantoins to the corresponding 2-iminoimidazolones is described employing tert.-butylhydroperoxide (TBHP) in the presence of aqueous ammonia. (C) 1997 Elsevier Science Ltd.

引用

页码：8935 / 8938

页数：4

共 15 条

[1]

Attaway D., 1993, MARINE BIOTECHNOLOGY, V1

[2] Dispacamides, anti-histamine alkaloids from Caribbean Agelas sponges [J].

Cafieri, F ;

Fattorusso, E ;

Mangoni, A ;

TaglialatelaScafati, O .

TETRAHEDRON LETTERS, 1996, 37 (20) :3587-3590

[3] NEW BROMO-PYRROLE DERIVATIVES FROM SPONGE AGELAS-OROIDES [J].

FORENZA, S ;

MINALE, L ;

RICCIO, R .

JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1971, (18) :1129-&

[4] REINVESTIGATION INTO STRUCTURE OF OROIDIN, A BROMOPYRROLE DERIVATIVE FROM MARINE SPONGE [J].

GARCIA, EE ;

BENJAMIN, LE ;

FRYER, RI .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1973, (03) :78-79

[5]

GRIBBLE GW, 1996, FORTSCHR CHEM ORG NA, V68, P137

[6] APLYSINOPSIN-TYPE ALKALOIDS FROM DENDROPHYLLIA SP, A SCLERACTINIAN CORAL OF THE FAMILY DENDROPHYLLIIDAE OF THE PHILIPPINES - FACILE PHOTOCHEMICAL (Z/E) PHOTOISOMERIZATION AND THERMAL REVERSAL [J].

GUELLA, G ;

MANCINI, I ;

ZIBROWIUS, H ;

PIETRA, F .

HELVETICA CHIMICA ACTA, 1989, 72 (07) :1444-1450

[7] NOVEL APLYSINOPSIN-TYPE ALKALOIDS FROM SCLERACTINIAN CORALS OF THE FAMILY DENDROPHYLLIIDAE OF THE MEDITERRANEAN AND THE PHILIPPINES - CONFIGURATIONAL-ASSIGNMENT CRITERIA, STEREOSPECIFIC SYNTHESIS, AND PHOTOISOMERIZATION [J].

GUELLA, G ;

MANCINI, I ;

ZIBROWIUS, H ;

PIETRA, F .

HELVETICA CHIMICA ACTA, 1988, 71 (04) :773-782

[8] HYDANTOINE, THIOHYDANTOINE, GLYKOCYAMIDINE .3. UBER DIE ORIENTIERUNG BEI DER MONOBENZYLIERUNG DES 5.5-DIPHENYL-GLYKOCYAMIDINS [J].

LEMPERT, K ;

BREUER, J ;

LEMPERTSRETER, M .

CHEMISCHE BERICHTE-RECUEIL, 1959, 92 (01) :235-239

[9]

Lindel T, 1997, LIEBIGS ANN-RECL, P1525

[10] A CONVENIENT SYNTHESIS OF GUANIDINES FROM THIOUREAS [J].

MARYANOFF, CA ;

STANZIONE, RC ;

PLAMPIN, JN ;

MILLS, JE .

JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (10) :1882-1884

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