Phosphinic platinum complexes with 8-thiotheophylline derivatives:: Synthesis, characterization, and antiproliferative activity

被引：61

作者：

Bergamini, P.

Bertolasi, V.

Marvelli, L.

Canella, A.

Gavioli, R.

Mantovani, N.

Manas, S.

Romerosa, A.

机构：

[1] Univ Ferrara, Dipartimento Chim, I-44100 Ferrara, Italy

[2] Univ Ferrara, Dipartimento Biochim & Biol Mol, I-44100 Ferrara, Italy

[3] Univ Almeria, Fac Ciencias Expt, Area Quin Inorgan, Almeria, Spain

来源：

INORGANIC CHEMISTRY | 2007年 / 46卷 / 10期

关键词：

D O I：

10.1021/ic062133c

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The platinum mixed-phosphine complexes (SP-4,2)-[PtCl(8-MTT)(PPh3)(PTA)] (2) and cis-[Pt(8-MTT)(2)(PPh3)(PTA)] (3) (MTTH2 = 8-(methylthio)theophylline, PTA = 1,3,5-triaza-7-phosphaadamantane) have been prepared from the precursor cis-[PtCl2(PPh3)(PTA)] (1), which has been fully characterized by X-ray diffraction determination. Antiproliferative activity tests indicated that the presence of one lipophilic PPh3 and one hydrophilic PTA makes 1-3 more active than the analogues bearing two PPh3 or two PTA. The reactivity of cis-[PtCl2(PPh3)(2)], cis-[PtCl2(PTA)(2)], and cis-[PtCl2(PPh3)(PTA)] with the bis(thiopurines) bis(S-8-thiotheophylline)methane (MBTTH2), 1,2-bis(S-8-thiotheophylline)ethane (EBTTH2), and 1,3-bis(S-8-thiotheophylline)propane (PBTTH2) has also been investigated. New binuclear complexes have been prepared and identified by spectroscopic techniques and their antiproliferative activities on T2 and SKOV3 cell lines evaluated.

引用

页码：4267 / 4276

页数：10

共 36 条

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