共 21 条
Efficient synthesis of β- and γ-amino acid derivatives using new functionalised zinc reagents:: enhanced stability and reactivity of β-amido zinc reagents in dimethylformamide
被引:30
作者:
Dexter, CS
[1
]
Jackson, RFW
[1
]
机构:
[1] Univ Newcastle Upon Tyne, Dept Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
关键词:
D O I:
10.1039/a707062d
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
The new zinc reagents 3 and 4 are not sufficiently stable to be prepared efficiently in THF, but they can be prepared in DMF under mild and convenient conditions; subsequent palladium-catalysed coupling with aromatic iodides gives protected beta- and gamma-amino acids 11 and 12 in generally good yields.
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页码:75 / 76
页数:2
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