The genome of non-O1 Vibrio cholerae NRT36S demonstrates the presence of pathogenic mechanisms that are distinct from those of O1 Vibrio cholerae

被引：41

作者：

Chen, Yuansha

Johnson, Judith A.

Pusch, Gordon D.

Morris, J. Glenn, Jr.

Stine, O. Colin

机构：

[1] Univ Maryland, Baltimore, MD 21201 USA

[2] Vet Affairs Maryland Hlth Care Syst, Baltimore, MD 21201 USA

[3] Natl Microbial Pathogen Data Resource, Chicago, IL USA

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 05期

关键词：

D O I：

10.1128/IAI.01317-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vibrio cholerae NRT36S is a non-cholera toxin-producing, non-O1 strain that causes diarrhea in volunteers. The genome of NRT36S was sequenced to create a draft containing 174 contigs plus the superintegron region. Our analysis of the draft genome revealed several putative toxin genes and colonization factors. Besides confirming the existence of nonagglutinable heat-stable toxin, we also identified the genes for a type three secretion system, a putative exotoxin, two different RTX toxins, and four pilus systems.

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页码：2645 / 2647

页数：3

相关论文

共 22 条

[1] PURIFICATION AND CHARACTERIZATION OF VIBRIO-CHOLERAE NON-O1 HEAT-STABLE ENTEROTOXIN [J].

ARITA, M ;

TAKEDA, T ;

HONDA, T ;

MIWATANI, T .

INFECTION AND IMMUNITY, 1986, 52 (01) :45-49

[2] Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar typhimurium DT104 and its identification in phage type DT120 and serovar agona [J].

Boyd, D ;

Peters, GA ;

Cloeckaert, A ;

Boumedine, KS ;

Chaslus-Dancla, E ;

Imberechts, E ;

Mulvey, MR .

JOURNAL OF BACTERIOLOGY, 2001, 183 (19) :5725-5732

[3] Comparative genome analysis of Vibrio vulnificus, a marine pathogen [J].

Chen, CY ;

Wu, KM ;

Chang, YC ;

Chang, CH ;

Tsai, HC ;

Liao, TL ;

Liu, YM ;

Chen, HJ ;

Shen, ABT ;

Li, JC ;

Su, TL ;

Shao, CP ;

Lee, CT ;

Hor, LI ;

Tsai, SF .

GENOME RESEARCH, 2003, 13 (12) :2577-2587

[4] The capsule polysaccharide structure and biogenesis for non-OI Vibrio cholerae NRT36S: genes are embedded in the LPS region [J].

Chen, Yuansha ;

Bystricky, Peter ;

Adeyeye, Jacob ;

Panigrahi, Pinaki ;

Ali, Afsar ;

Johnson, Judith A. ;

Bush, C. A. ;

Morris, J. G., Jr. ;

Stine, O. C. .

BMC MICROBIOLOGY, 2007, 7

[5] Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system [J].

Dziejman, M ;

Serruto, D ;

Tam, VC ;

Sturtevant, D ;

Diraphat, P ;

Faruque, SM ;

Rahman, MH ;

Heidelberg, JF ;

Decker, J ;

Li, L ;

Montgomery, KT ;

Grills, G ;

Kucherlapati, R ;

Mekalanos, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (09) :3465-3470

[6] Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio cholerae [J].

Fullner, KJ ;

Mekalanos, JJ .

INFECTION AND IMMUNITY, 1999, 67 (03) :1393-1404

[7] ROLE OF VIBRIO-CHOLERAE NEURAMINIDASE IN THE FUNCTION OF CHOLERA-TOXIN [J].

GALEN, JE ;

KETLEY, JM ;

FASANO, A ;

RICHARDSON, SH ;

WASSERMAN, SS ;

KAPER, JB .

INFECTION AND IMMUNITY, 1992, 60 (02) :406-415

[8] DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae [J].

Heidelberg, JF ;

Eisen, JA ;

Nelson, WC ;

Clayton, RA ;

Gwinn, ML ;

Dodson, RJ ;

Haft, DH ;

Hickey, EK ;

Peterson, JD ;

Umayam, L ;

Gill, SR ;

Nelson, KE ;

Read, TD ;

Tettelin, H ;

Richardson, D ;

Ermolaeva, MD ;

Vamathevan, J ;

Bass, S ;

Qin, HY ;

Dragoi, I ;

Sellers, P ;

McDonald, L ;

Utterback, T ;

Fleishmann, RD ;

Nierman, WC ;

White, O ;

Salzberg, SL ;

Smith, HO ;

Colwell, RR ;

Mekalanos, JJ ;

Venter, JC ;

Fraser, CM .

NATURE, 2000, 406 (6795) :477-483

[9] TOXIN, TOXIN-COREGULATED PILI, AND THE TOXR REGULON ARE ESSENTIAL FOR VIBRIO-CHOLERAE PATHOGENESIS IN HUMANS [J].

HERRINGTON, DA ;

HALL, RH ;

LOSONSKY, G ;

MEKALANOS, JJ ;

TAYLOR, RK ;

LEVINE, MM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (04) :1487-1492

[10] Characterization of a novel Vibrio pathogenicity island (VPI-2) encoding neuraminidase (nanH) among toxigenic Vibrio cholerae isolates [J].

Jermyn, WS ;

Boyd, EF .

MICROBIOLOGY-SGM, 2002, 148 :3681-3693