Age-related changes in trabecular architecture differ in female and male C57BL/6J mice

被引：484

作者：

Glatt, Vaida

Canalis, Ernesto

Stadmeyer, Lisa

Bouxsein, Mary L.

机构：

[1] Beth Israel Deaconess Med Ctr, Orthopaed Biomech Lab, RN 115, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] St Francis Hosp & Med Ctr, Dept Res, Hartford, CT 06105 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 08期

关键词：

murine; trabecular bone; aging; microarchitecture;

D O I：

10.1359/JBMR.070507

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We used mu CT and histomorphometry to assess age-related changes in bone architecture in male and female C57BL/6J mice. Deterioration in vertebral and femoral trabecular microarchitecture begins early, continues throughout life, is more pronounced at the femoral metaphysis than in the vertebrae, and is greater in females than males.

引用

页码：1197 / 1207

页数：11

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