A convenient synthesis of the paclitaxel side-chain via a diastereoselective Staudinger reaction

被引：16

作者：

Brown, S

Jordan, AM

Lawrence, NJ

Pritchard, RG

McGown, AT

机构：

[1] Univ Manchester, Inst Sci & Technol, Dept Chem, Manchester M60 1QD, Lancs, England

[2] Christie Hosp NHS Trust, Paterson Inst Canc Res, CRC, Dept Drug Dev, Manchester M20 4BX, Lancs, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(98)00548-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The N-benzylidene derivative of (S)-(-)-1-(p-methoxyphenyl)propyl-1-amine, obtained by a new resolution procedure, exhibits moderate selectivity in the reaction with 2-acetoxyketene; the (S)-(-)-1-(p-methoxyphenyl)propyl group can be oxidatively cleaved from the resultant beta-lactam, an important precursor for taxane semi-synthesis. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3559 / 3562

页数：4

共 26 条

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