The first synthesis of peptide thioester carrying N-linked core pentasaccharide through modified Fmoc thioester preparation:: synthesis of an N-glycosylated Ig domain of emmprin

被引：67

作者：

Hojo, H ^{[1
]}

Haginoya, E

Matsumoto, Y

Nakahara, Y

Nabeshima, K

Toole, BP

Watanabe, Y

机构：

[1] Tokai Univ, Dept Appl Biochem, Kanagawa 2591292, Japan

[2] Fukuoka Univ Hosp, Dept Pathol, Sch Med, Fukuoka 8140180, Japan

[3] Tufts Univ, Sch Med, Dept Anat & Cellular Biol, Medford, MA 02111 USA

[4] Natl Food Res Inst, Protein Lab, Tsukuba 3058642, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(03)00394-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Peptide thioester carrying N-linked core pentasaccharide was prepared by the Fmoc solid-phase method with a combination of the benzyl-protection strategy at the carbohydrate portion. The obtained peptide thioester was successfully used for the synthesis of the first Ig domain of emmprin composed of 61 amino acid residues. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2961 / 2964

页数：4

共 26 条

[1]

Aimoto S, 1999, BIOPOLYMERS, V51, P247, DOI 10.1002/(SICI)1097-0282(1999)51:4<247::AID-BIP2>3.0.CO

[2]

2-W

[3] Backbone amide linker (BAL) strategy for Nα-9-fluorenylmethoxycarbonyl (Fmoc) solid-phase synthesis of unprotected peptide p-nitroanilides and thioesters [J].