Etiology of Type 1 Diabetes

被引：398

作者：

Todd, John A. ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge Inst Med Res, Dept Med Genet, Juvenile Diabet Res Fdn,Wellcome Trust Diabet & I, Cambridge CB2 0XY, England

来源：

IMMUNITY | 2010年 / 32卷 / 04期

基金：

英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; T-CELLS; GENETIC-VARIANTS; INTESTINAL MICROBIOTA; LYMPHOCYTE DEPLETION; MULTIPLE-SCLEROSIS; INTERFERON-ALPHA; COMMON VARIANTS; BETA-CELLS; HLA-B;

D O I：

10.1016/j.immuni.2010.04.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent genetic mapping and gene-phenotype studies have revealed the genetic architecture of type 1 diabetes. At least ten genes so far can be singled out as strong causal candidates. The known functions of these genes indicate the primary etiological pathways of this disease, including HLA class II and I molecules binding to preproinsulin peptides and T cell receptors, T and B cell activation, innate pathogen-viral responses, chemokine and cytokine signaling, and T regulatory and antigen-presenting cell functions. This review considers research in the field of type 1 diabetes toward identifying disease mechanisms using genetic approaches. The expression and functions of these pathways, and, therefore, disease susceptibility, will be influenced by epigenetic and environmental factors. Certain inherited immune phenotypes will be early precursors of type 1 diabetes and could be useful in future clinical trials.

引用

页码：457 / 467

页数：11

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