Th17 and Cognitive Impairment: Possible Mechanisms of Action

被引：97

作者：

Cipollini, Virginia ^{[1
]}

Anrather, Josef ^{[2
]}

Orzi, Francesco ^{[1
]}

Iadecola, Costantino ^{[2
]}

机构：

[1] Sapienza Univ Rome, St Andrea Hosp, Rome, Italy

[2] Weill Cornell Med, Feil Family Brain & Mind Res Inst, New York, NY USA

来源：

FRONTIERS IN NEUROANATOMY | 2019年 / 13卷

关键词：

Th17; cells; IL-17; cytokine; cognitive impairment; neuroinflammation; immune system; central nervous system; BLOOD-BRAIN-BARRIER; CENTRAL-NERVOUS-SYSTEM; ALPHA-4 INTEGRIN EXPRESSION; II-INDUCED HYPERTENSION; NECROSIS-FACTOR-ALPHA; DELTA-T-CELLS; CHOROID-PLEXUS; MULTIPLE-SCLEROSIS; NEUROVASCULAR UNIT; T(H)17 CELLS;

D O I：

10.3389/fnana.2019.00095

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100123 [人体微生态学]; 100210 [外科学];

摘要：

T helper 17 (Th17) cells represent a distinct population of immune cells, important in the defense of the organism against extracellular infectious agents. Because of their cytokine profile and ability to recruit other immune cell types, they are highly pro-inflammatory and are involved in the induction of several autoimmune disorders. Recent studies show that Th17 cells and their signature cytokine IL-17 have also a role in a wide variety of neurological diseases. This review article will briefly summarize the evidence linking Th17 cells to brain diseases associated with cognitive impairment, including multiple sclerosis (MS), ischemic brain injury and Alzheimer's disease (AD). We will also investigate the mechanisms by which these cells enter the brain and induce brain damage, including direct effects of IL-17 on brain cells and indirect effects mediated through disruption of the blood-brain barrier (BBB), neurovascular dysfunction and gut-brain axis. Finally, therapeutic prospects targeting Th17 cells and IL-17 will be discussed.

引用

页数：12

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