Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation

被引：105

作者：

Alvarez, Mario M. ^{[1
,3
,4
,11
]}

Aizenberg, Joanna ^{[12
,13
,14
,15
]}

Analoui, Mostafa ^{[16
]}

Andrews, Anne M. ^{[17
,18
,19
,20
]}

Bisker, Gill ^{[5
]}

Boyden, Edward S. ^{[6
,7
,8
,9
]}

Kamm, Roger D. ^{[9
,10
]}

Karp, Jeffrey M. ^{[3
]}

Mooney, David J. ^{[15
]}

Oklu, Rahmi ^{[2
,22
]}

Peer, Dan ^{[23
,24
,25
]}

Stolzoff, Michelle ^{[26
,27
]}

Strano, Michael S. ^{[5
]}

Trujillo-de Santiago, Grissel ^{[1
,3
,4
,11
]}

Webster, Thomas J. ^{[26
,27
,31
]}

Weiss, Paul S. ^{[17
,18
,21
]}

Khademhosseini, Ali ^{[1
,3
,4
,28
,29
,30
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr,Div Biomed Engn, Boston, MA 02139 USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Boston, MA 02139 USA

[3] MIT, Harvard Massachusetts Inst Technol, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[4] MIT, Microsyst Technol Labs, Cambridge, MA 02139 USA

[5] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[6] MIT, Media Lab, Cambridge, MA 02139 USA

[7] MIT, McGovern Inst, Cambridge, MA 02139 USA

[8] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[9] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[10] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

[11] Ctr Biotecnol FEMSA, Tecnol Monterrey, Ave Eugenio Garza Sada 2501,Col Tecnol,CP 64849, Monterrey, Nuevo Leon, Mexico

[12] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

[13] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA

[14] Harvard Univ, Kavli Inst Bionano Sci & Technol, Cambridge, MA 02138 USA

[15] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[16] UConn, UConn Venture Dev & Incubation, Storrs, CT 06269 USA

[17] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[18] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[19] Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90095 USA

[20] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA

[21] Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA

[22] Mayo Clin, Div Intervent Radiol, Scottsdale, AZ 85259 USA

[23] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, Lab Precis NanoMed, IL-69978 Tel Aviv, Israel

[24] Tel Aviv Univ, Thy & Aladar Fleischman Fac Engn, Dept Mat Sci & Engn, IL-69978 Tel Aviv, Israel

[25] Tel Aviv Univ, Ctr Nanosci & Nanotechnol, IL-69978 Tel Aviv, Israel

[26] Northeastern Univ, Dept Bioengn, Boston, MA 02115 USA

[27] Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA

[28] King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Jeddah 23218, Saudi Arabia

[29] King Abdulaziz Univ, Dept Phys, Jeddah 23218, Saudi Arabia

[30] Konkuk Univ, Coll Anim Bioscience & Technol, Dep Bioind Technol, Seoul 143701, South Korea

[31] Wenzhou Med Univ, Wenzhou Inst Biomat & Engn, Wenzhou 325000, Peoples R China

来源：

ACS NANO | 2017年 / 11卷 / 06期

关键词：

CIRCULATING TUMOR-CELLS; MESOPOROUS SILICA NANOPARTICLES; PHASE MOLECULAR RECOGNITION; ON-A-CHIP; MICROFLUIDIC PLATFORM; IN-VITRO; EXPANSION MICROSCOPY; CARBON NANOTUBES; DRUG-RESISTANCE; DELIVERY;

D O I：

10.1021/acsnano.7b01493

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

We discuss the state of the art and innovative micro- and nano scale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care applications and the capture of circulating tumor cells as illustrative examples of the integration of micro- and nanotechnologies into solutions of diagnostic challenges. We describe several novel nanotechnologies that enable imaging cellular structures and molecular events. In therapeutics, we describe the utilization of micro- and nanotechnologies in applications including drug delivery, tissue engineering, and pharmaceutical development/testing. In addition, we discuss relevant challenges that micro- and nanotechnologies face in achieving cost-effective and widespread clinical implementation as well as forecasted applications of micro- and nanotechnologies in medicine.

引用

页码：5195 / 5214

页数：20

共 188 条

[31]

Cell migration into scaffolds under co-culture conditions in a microfluidic platform [J].