New strategies for the manipulation of adaptive immune responses

被引：17

作者：

Bopp, Tobias ^{[1
]}

Radsak, Markus ^{[1
,2
]}

Schmitt, Edgar ^{[1
]}

Schild, Hansjoerg ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Immunol, D-55131 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Med Clin 3, D-55131 Mainz, Germany

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2010年 / 59卷 / 09期

关键词：

Regulatory T cells; Dendritic cells; cAMP; Gap junctions; Immune regulation; REGULATORY T-CELLS; CAMP-ELEVATING AGENTS; DENDRITIC CELLS; CYCLIC-AMP; PROTEIN-KINASE; SUPPRESSION; ACTIVATION; AUTOIMMUNE; DEPLETION; ATTENUATION;

D O I：

10.1007/s00262-010-0851-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The maintenance of peripheral tolerance is largely based on thymus-derived CD4(+)CD25(+) naturally occurring regulatory T cells (Tregs). While on the one hand being indispensable for the perpetuation of tolerance to self-antigens, the immune suppressive properties of Tregs contribute to cancer pathogenesis and progression. Thus, modulation of Treg function represents a promising strategy to support tumor eradication in immunotherapy of cancer. Here, we discuss potential therapeutic applications of our observation that Tregs contain high concentrations of the second messenger cyclic adenosine monophosphate, which is transferred from Tregs via gap junctions to suppress the function of T cells and dendritic cells.

引用

收藏

页码：1443 / 1448

页数：6

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