Serum steroid hormone levels, sex hormone binding globulin, and body mass index in the etiology of postmenopausal breast cancer

被引：78

作者：

Lipworth, L

Adami, HO

Trichopoulos, D

Carlestrom, K

Mantzoros, C

机构：

[1] Department of Epidemiology, Harvard School of Public Health, Boston, MA

[2] Department of Cancer Epidemiology, Uppsala University, Uppsala

[3] Department of Obstetrics, Karolinska Institute, Huddinge University Hospital, Huddinge

[4] Department of Endocrinology, Beth Israel Hospital, Boston, MA

[5] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115

来源：

EPIDEMIOLOGY | 1996年 / 7卷 / 01期

关键词：

estrone; androstenedione; testosterone; SHBG; breast cancer;

D O I：

10.1097/00001648-199601000-00017

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Serum concentrations of estrone, androstenedione, testosterone, and sex hormone-binding globulin (SHBG) were measured postoperatively in 122 postmenopausal women with incident breast cancer and 122 age-matched population controls. After mutual adjustment, through conditional logistic regression, between the hormonal variables and body mass index (BMI), the odds ratios for increasing control-defined quartiles of estrone and androstenedione, respectively, were 1.00, 1.44, 1.76, 1.94 and 1.00, 0.83, 0.97, 2.43; there was no association of testosterone with breast cancer risk. Moreover, the odds ratios for increasing quartiles of SHBG and BMI were 1.00, 0.72, 0.28, 0.25 and 1.00, 0.39, 0.28, 0.19, respectively. This study reveals sharp contrasts in breast cancer risk between women with high estrone and low BMI and SHBG, vs women with low estrone and high BMI and SHBG.

引用

页码：96 / 100

页数：5

共 67 条

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