Protic ionic liquid [TMG][Ac] as an efficient, homogeneous and recyclable catalyst for Boc protection of amines

被引：34

作者：

Akbari, Jafar ^{[1
]}

Heydari, Akbar ^{[1
]}

Ma'mani, Leila ^{[1
]}

Hosseini, Seyed Hassan ^{[1
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

COMPTES RENDUS CHIMIE | 2010年 / 13卷 / 05期

关键词：

Protic ionic liquid; Amine protection; Boc derivatives; di-tert-butyl dicarbonate; N-TERT-BUTOXYCARBONYLATION; HIGHLY EFFICIENT; ACID; REAGENT;

D O I：

10.1016/j.crci.2009.10.003

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and practical protocol for the chemoselective N-Boc protection of various structurally different aryl, aliphatic and heterocyclic amines was carried out with (Boc)(2)O using protic 1, 1, 3, 3-tetra-methylguanidinium acetate (10 mol%) as recyclable catalyst under solvent free condition at ambient temperature. No competitive side reactions (isocyanate, urea and N, N-di-Boc) were observed, alpha-Amino alcohols afforded the N-Boc-derivative without oxazolidinone formation. (C) 2009 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

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收藏

页码：544 / 547

页数：4

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