A highly chemoselective Boc protection of amines using sulfonic-acid-functionalized silica as an efficient heterogeneous recyclable catalyst

被引：65

作者：

Das, Biswanath ^{[1
]}

Venkateswarlu, Katta ^{[1
]}

Krishnaiah, Maddeboina ^{[1
]}

Holla, Harish ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 43期

关键词：

amine; Boc protection; (Boc)(2)O; sulfonic-acid-functionalized silica; heterogeneous recyclable catalyst;

D O I：

10.1016/j.tetlet.2006.08.093

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and versatile method for the chemoselective Boc protection of amines has been developed by a treatment with (Boc)(2)O in the presence of sulfonic-acid-functionalized silica as a catalyst. The method is general for the preparation of N-Boc derivatives of aliphatic (acyclic and cyclic), aromatic, and heteroaromatic amines; primary and secondary amines; aminols, amino-esters; and sulfonamides. The catalyst works under heterogeneous conditions and can be recycled. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7551 / 7556

页数：6

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