Argonautes and company: Sailing against the wind

被引：20

作者：

Bhattacharyya, Suvendra N. ^{[1
]}

Filipowicz, Witold ^{[1
]}

机构：

[1] Friedrich Miescher Inst, CH-4002 Basel, Switzerland

来源：

CELL | 2007年 / 128卷 / 06期

关键词：

D O I：

10.1016/j.cell.2007.02.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 3'-untranslated region (UTR) of mRNA is crucial for posttranscriptional regulation. In this issue, Vasudevan and Steitz (2007) report a new function for AGO2 and FXR1 - two proteins that have been linked to the regulation of microRNAs and translation repression. AGO2 and FXR1 bind to the AU-rich element in the 3'-UTR of TNF alpha mRNA, unexpectedly activating its translation in a cell growth-dependent manner.

引用

页码：1027 / 1028

页数：2

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