Longevity genes: from primitive organisms to humans

被引：44

作者：

Warner, HR ^{[1
]}

机构：

[1] NIA, Biol Aging Program, Bethesda, MD 20892 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2005年 / 126卷 / 02期

关键词：

aging; longevity; stress resistance; caloric restriction; insulin-signaling;

D O I：

10.1016/j.mad.2004.08.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent results indicate that the longevity of both invertebrates and vertebrates can be altered through genetic manipulation and pharmacological intervention. Most of these interventions involve alterations of one or more of the following: insulin/IGF-I signaling pathway, caloric intake, stress resistance and nuclear structure. How longevity regulation relates to aging per se is less clear, but longevity increases are usually accompanied by extended periods of good health. How these results will translate to primate aging and longevity remains to be shown. Published by Elsevier Ireland Ltd.

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页码：235 / 242

页数：8

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