Advances in zinc finger engineering

被引：64

作者：

Choo, Y

Isalan, M

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[2] Gendaq Ltd, London NW7 1AD, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2000年 / 10卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(00)00107-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently developments have been made in engineering sequence-specific zinc finger DNA-binding proteins. Advances in this area will soon make it routine to target proteins to specific DNA sequences associated with any given gene. The primary interest is in the regulation of gene expression using customised transcription factors. However, modular catalytic domains are also being developed in order to engineer chimaeric proteins with customised restriction enzyme, methylase and integrase activity.

引用

收藏

页码：411 / 416

页数：6

相关论文

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