Enhanced mixing in double-cone blenders

被引:76
作者
Brone, D [1 ]
Muzzio, FJ [1 ]
机构
[1] Rutgers State Univ, Dept Chem & Biochem Engn, Piscataway, NJ 08855 USA
关键词
double-cone blenders; powder blending; powder mixing; blend homogeneity;
D O I
10.1016/S0032-5910(99)00204-1
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Experiments were conducted comparing mixing performance in a conventional double-cone blender and in a double-cone blender that was modified by means of a stationary deflector plate in order to enhance axial particle flow. Mixing performance was assessed qualitatively using a transparent mixing vessel to visualize particle mixing patterns and determine the state of homogeneity at the mixture's surface during the entire experiment. Mixing performance was also examined quantitatively by repeatedly vacuuming several layers of beads, taking a digital image of the bed after vacuuming, and using image analysis to subdivide the images into samples and determine the composition of each sample. The effect of operating conditions (rotation rate, vessel fill percentage and total number of revolutions) was examined. Mixing was quantified in terms of the standard deviation of the concentration of a tracer. The evolution of the process was accurately described by a single-parameter model that characterized axial mixing as a first order process with a characteristic rate constant. For double-cone mixers of standard design, under all operating conditions, slow flow of particles through a vertical plane of symmetry at the center of the vessel caused poor mixing performance, insertion of a deflector plate inclined relative to this plane was very effective in enhancing mixing. The effect of the deflector was to create a convective axial flow across the center of the mixer, increasing the mixing rate by a factor of 25:1. (C) 2000 Elsevier Science S.A. All rights reserved.
引用
收藏
页码:179 / 189
页数:11
相关论文
共 18 条
[1]  
ASHTON MD, 1966, T I CHEM ENG-LOND, V44, P166
[2]   BLEND UNIFORMITY AND UNIT DOSE SAMPLING [J].
BERMAN, J ;
PLANCHARD, JA .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1995, 21 (11) :1257-1283
[3]   Using flow perturbations to enhance mixing of dry powders in V-blenders [J].
Brone, D ;
Wightman, C ;
Connor, K ;
Alexander, A ;
Muzzio, FJ ;
Robinson, P .
POWDER TECHNOLOGY, 1997, 91 (03) :165-172
[4]   Quantitative characterization of mixing of dry powders in V-blenders [J].
Brone, D ;
Alexander, A ;
Muzzio, FJ .
AICHE JOURNAL, 1998, 44 (02) :271-278
[5]   THE MIXING OF SOLIDS IN TUMBLING MIXERS .2. [J].
CARLEYMACAULY, KW ;
DONALD, MB .
CHEMICAL ENGINEERING SCIENCE, 1964, 19 (03) :191-&
[6]   THE MIXING OF SOLIDS IN TUMBLING MIXERS .1. [J].
CARLEYMACAULY, KW ;
DONALD, MB .
CHEMICAL ENGINEERING SCIENCE, 1962, 17 (07) :493-&
[7]  
CHANG RK, 1991, INT J PHARM, V80, P171
[8]   Mixing dynamics in catalyst impregnation in double-cone blenders [J].
Chester, AW ;
Kowalski, JA ;
Coles, ME ;
Muegge, EL ;
Muzzio, FJ ;
Brone, D .
POWDER TECHNOLOGY, 1999, 102 (01) :85-94
[9]   RECENT DEVELOPMENTS IN SOLIDS MIXING [J].
FAN, LT ;
CHEN, YM ;
LAI, FS .
POWDER TECHNOLOGY, 1990, 61 (03) :255-287
[10]  
GRAY JB, 1957, CHEM ENG PROG, V53, P25