The multiple functions of tumour suppressors: it's all in APC

被引：51

作者：

Fodde, R ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Ctr Human & Clin Genet, NL-2300 RA Leiden, Netherlands

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 03期

关键词：

D O I：

10.1038/ncb0303-190

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The multi-functionality of the adenomatous polyposis coli (APC) tumour suppressor gene keeps surprising cancer molecular biologists. Signal transduction, cytoskeletal organization, chromosomal segregation and cell adhesion are just some of the putative cellular functions previously assigned to this gene and thought to be related to its tumour-suppressing activity. New data on yet another tumour-related function of APC, namely the coordinated regulation of cell adhesion and motility, adds to its host of cellular activities.

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页码：190 / 192

页数：4

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