Synthesis of Enol Ethers and Enamines by Pd-Catalyzed Tosylhydrazide-Promoted Cross-Coupling Reactions

被引:91
作者
Barluenga, Jose [1 ]
Escribano, Maria [1 ]
Moriel, Patricia [1 ]
Aznar, Fernando [1 ]
Valdes, Carlos [1 ]
机构
[1] Univ Oviedo, Inst Univ Quim Organomet Enrique Moles, E-33006 Oviedo, Spain
关键词
cross-coupling; enamines; enol ethers; hydrazones; palladium; CARBENE INSERTION; ALPHA-ARYLATION; BOND FORMATION; ARYL BROMIDES; VINYL HALIDES; PALLADIUM; ALDEHYDES; CLEAVAGE;
D O I
10.1002/chem.200902718
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
"Chemical Equation Presented" α-Substitution is fine: α-Alkoxycarbonyl and α-aminocarbonyl compounds are good substrates for the recently developed tosylhydrazide-promoted Pd-catalyzed cross-coupling of carbonyls with aryl halides. The reac-tion gives rise to enol ethers and enamines, respectively, which are useful synthetic intermediates in heterocyclic synthesis. Otherwise, they can be hydrolyzed to give α,α- disubstituted aldehydes. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:13291 / 13294
页数:4
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