A concise and efficient solid-phase synthesis of 2-amino-4(3H)-quinazolinones

被引：65

作者：

Yang, RY ^{[1
]}

Kaplan, A ^{[1
]}

机构：

[1] ArQule Inc, Woburn, MA 01801 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 36期

关键词：

quinazolinones; thioformamidines; solid-phase synthesis;

D O I：

10.1016/S0040-4039(00)01201-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise and efficient solid-phase synthesis of 2-amino-4(3H)-quinazolinones is described. Reaction of polymer-bound isothiourea with isatoic anhydride provides 2-amino-4(3H)-quinazolinones with good yields and excellent purity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7005 / 7008

页数：4

共 21 条

[21] DESIGN OF THYMIDYLATE SYNTHASE INHIBITORS USING PROTEIN CRYSTAL-STRUCTURES - THE SYNTHESIS AND BIOLOGICAL EVALUATION OF A NOVEL CLASS OF 5-SUBSTITUTED QUINAZOLINONES [J].

WEBBER, SE ;

BLECKMAN, TM ;

ATTARD, J ;

DEAL, JG ;

KATHARDEKAR, V ;

WELSH, KM ;

WEBBER, S ;

JANSON, CA ;

MATTHEWS, DA ;

SMITH, WW ;

FREER, ST ;

JORDAN, SR ;

BACQUET, RJ ;

HOWLAND, EF ;

BOOTH, CLJ ;

WARD, RW ;

HERMANN, SM ;

WHITE, J ;

MORSE, CA ;

HILLIARD, JA ;

BARTLETT, CA .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (06) :733-746

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