Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development

被引：110

作者：

Feng, Xiaoming ^{[1
,2
]}

Ippolito, Gregory C. ^{[3
,4
]}

Tian, Lifeng ^{[1
,2
]}

Wiehagen, Karla ^{[1
,2
]}

Oh, Soyoung ^{[1
,2
]}

Sambandam, Arivazhagan ^{[5
]}

Willen, Jessica ^{[1
,2
]}

Bunte, Ralph M. ^{[6
]}

Maika, Shanna D. ^{[3
,4
]}

Harriss, June V. ^{[3
,4
]}

Caton, Andrew J. ^{[1
,2
]}

Bhandoola, Avinash ^{[5
]}

Tucker, Philip W. ^{[3
,4
]}

Hu, Hui ^{[1
,2
]}

机构：

[1] Wistar Inst Anat & Biol, Program Immunol, Philadelphia, PA 19104 USA

[2] Wistar Inst Anat & Biol, Wistar Vaccine Ctr, Philadelphia, PA 19104 USA

[3] Univ Texas Austin, Dept Mol Genet, Austin, TX 78712 USA

[4] Univ Texas Austin, Inst Mol & Cellular Biol, Austin, TX 78712 USA

[5] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[6] Univ Penn, Univ Lab Anim Resources, Philadelphia, PA 19104 USA

来源：

BLOOD | 2010年 / 115卷 / 03期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; POSITIVE SELECTION; RECEPTOR; DIFFERENTIATION; ACTIVATION; EXPRESSION; FOXO1; MODULATION; SURVIVAL; SIGNALS;

D O I：

10.1182/blood-2009-07-232694

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Proper thymocyte development is required to establish T-cell central tolerance and to generate naive T cells, both of which are essential for T-cell homeostasis and a functional immune system. Here we demonstrate that the loss of transcription factor Foxp1 results in the abnormal development of T cells. Instead of generating naive T cells, Foxp1-deficient single-positive thymocytes acquire an activated phenotype prematurely in the thymus and lead to the generation of peripheral CD4(+) T and CD8(+) T cells that exhibit an activated phenotype and increased apoptosis and readily produce cytokines upon T-cell receptor engagement. These results identify Foxp1 as an essential transcriptional regulator for thymocyte development and the generation of quiescent naive T cells. (Blood. 2010; 115: 510-518)

引用

页码：510 / 518

页数：9

共 49 条

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