Pathobiology of neutrophil transepithelial migration: Implications in mediating epithelial injury

被引：94

作者：

Chin, Alex C. ^{[1
]}

Parkos, Charles A. ^{[1
]}

机构：

[1] Emory Univ, Dept Pathol & Lab Med, Epithelial Pathobiol Unit, Atlanta, GA 30322 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2007年 / 2卷

关键词：

inflammation; apical junction complex; permeability; surface receptors; signaling;

D O I：

10.1146/annurev.pathol.2.010506.091944

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Neutrophil (also known as polymorphonuclear leukocyte, or PMN) transepithelial migration and accumulation at mucosal surfaces is a hallmark of many inflammatory conditions. This process correlates directly with clinical disease activity and epithelial injury Currently, the mechanisms that define PMN epithelial interactions during an inflammatory response are not completely understood. This review, provides an overview of the consequences of PMN infiltration into epithelial tissues and highlights molecular details of PAIN epithelial interactions during transmigration. A better understanding of this process will likely provide new insights into developing organ-specific treatment strategies to reduce the deleterious consequences of epithelial inflammation.

引用

页码：111 / 143

页数：33

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