Staudinger ligation: A peptide from a thioester and azide

被引：428

作者：

Nilsson, BL

Kiessling, LL

Raines, RT

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 13期

关键词：

D O I：

10.1021/ol0060174

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The technique of native chemical ligation enables the total chemical synthesis of proteins. This method is limited, however, by an absolute requirement for a cysteine residue at the ligation juncture. Here, this restriction is overcome with a new chemical ligation method in which a phosphinobenzenethiol is used to link a thioester and azide. The product is an amide with no residual atoms.

引用

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页码：1939 / 1941

页数：3

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