Family History in Public Health Practice: A Genomic Tool for Disease Prevention and Health Promotion

被引：179

作者：

Valdez, Rodolfo ^{[1
]}

Yoon, Paula W. ^{[2
]}

Qureshi, Nadeem ^{[3
]}

Green, Ridgely Fisk ^{[4
]}

Khoury, Muin J. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA

[2] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA

[3] Univ Nottingham, Div Primary Care, Nottingham, England

[4] Ctr Dis Control & Prevent, Div Birth Defects & Dev Disabil, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA

来源：

ANNUAL REVIEW OF PUBLIC HEALTH, VOL 31 | 2010年 / 31卷

关键词：

risk factors; public health tool; screening; risk assessment; health promotion; chronic disease; cancer; cardiovascular disease; diabetes; CORONARY-HEART-DISEASE; GENETIC RISK-ASSESSMENT; PARENTAL CARDIOVASCULAR-DISEASE; RANDOMIZED CONTROLLED-TRIAL; COMPUTER DECISION-SUPPORT; MIDDLE-AGED ADULTS; BREAST-CANCER; PRIMARY-CARE; ATHEROSCLEROSIS RISK; PSYCHOLOGICAL IMPACT;

D O I：

10.1146/annurev.publhealth.012809.103621

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Family history is a risk factor for many chronic diseases, including cancer, cardiovascular disease, and diabetes. Professional guidelines usually include family history to assess health risk, initiate interventions, and motivate behavioral changes. The advantages of family history over other genomic tools include a lower cost, greater acceptability, and a reflection of shared genetic and environmental factors. However, the utility of family history in public health has been poorly explored. To establish family history as a public health tool, it needs to be evaluated within the ACCE framework (analytical validity; clinical validity; clinical utility; and ethical, legal, and social issues). Currently, private and I public organizations are developing tools to collect standardized family histories of many diseases. Their goal is to create family history tools that have decision support capabilities and are compatible with electronic health records. These advances will help realize the potential of family history as a public health tool.

引用

页码：69 / 87

页数：19

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