Therapeutic intervention and signaling

被引：48

作者：

Heimbrook, DC ^{[1
]}

Oliff, A ^{[1
]}

机构：

[1] Merck Res Labs, Dept Canc Res, W Point, PA 19486 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(98)80152-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Significant advances in our understanding of intracellular signal transduction pathways have emerged within the past several years. It is now apparent that, under certain circumstances, particular isoforms of Ras can be prenylated by geranylgeranyl protein transferase as well as farnesyl protein transferase. New pathways controlling growth factor-dependent inhibition of apoptosis involving phosphoinositide 3'-hydroxykinase and the protein kinase Akt have also been clarified. (C) Current Biology Ltd ISSN 0955-0674.

引用

页码：284 / 288

页数：5

共 40 条

[1] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha [J].

Alessi, DR ;

James, SR ;

Downes, CP ;

Holmes, AB ;

Gaffney, PRJ ;

Reese, CB ;

Cohen, P .

CURRENT BIOLOGY, 1997, 7 (04) :261-269

[2]

ALESSI DR, 1995, P NATL ACAD SCI USA, V92, P7686

[3]

BOS JL, 1989, CANCER RES, V49, P4682

[4] Modulation of Ras and a-factor function by carboxyl-terminal proteolysis [J].

Boyartchuk, VL ;

Ashby, MN ;

Rine, J .

SCIENCE, 1997, 275 (5307) :1796-1800

[5] PROTEIN-KINASE-B (C-AKT) IN PHOSPHATIDYLINOSITOL-3-OH INASE SIGNAL-TRANSDUCTION [J].

BURGERING, BMT ;

COFFER, PJ .

NATURE, 1995, 376 (6541) :599-602

[6]

Clark GJ, 1997, J BIOL CHEM, V272, P10608

[7] SPECIFIC ISOPRENOID MODIFICATION IS REQUIRED FOR FUNCTION OF NORMAL, BUT NOT ONCOGENIC, RAS PROTEIN [J].

COX, AD ;

HISAKA, MM ;

BUSS, JE ;

DER, CJ .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (06) :2606-2615

[8]

delPeso L, 1997, SCIENCE, V278, P687

[9] Regulation of neuronal survival by the serine-threonine protein kinase Akt [J].

Dudek, H ;

Datta, SR ;

Franke, TF ;

Birnbaum, MJ ;

Yao, RJ ;

Cooper, GM ;

Segal, RA ;

Kaplan, DR ;

Greenberg, ME .

SCIENCE, 1997, 275 (5300) :661-665

[10] PI3K: Downstream AKTion blocks apoptosis [J].

Franke, TF ;

Kaplan, DR ;

Cantley, LC .

CELL, 1997, 88 (04) :435-437

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