Interferon-α and -β in kidney inflammation

被引：69

作者：

Anders, Hans-Joachim ^{[1
]}

Lichtnekert, Julia ^{[1
]}

Allam, Ramanjaneyulu ^{[1
]}

机构：

[1] Univ Munich, Dept Nephrol, Med Poliklin, LMU, D-80336 Munich, Germany

来源：

KIDNEY INTERNATIONAL | 2010年 / 77卷 / 10期

关键词：

inflammation; innate immunity; interferon; Toll-like receptor; viral infection; TOLL-LIKE RECEPTORS; IMMUNE-COMPLEX GLOMERULONEPHRITIS; DOUBLE-STRANDED-RNA; I-INTERFERON; LUPUS-PRONE; AUTOANTIBODY PRODUCTION; ANTIVIRAL RESPONSES; CYTOSOLIC DNA; RECOGNITION; DISEASE;

D O I：

10.1038/ki.2010.71

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Type I interferons, interferon-alpha and interferon-beta, are central regulators of antiviral immunity and autoimmunity, but little is known about their role in renal inflammation. Recent work documents that viral nucleic acids are potent inducers of interferon-alpha and interferon-beta in mesangial cells and glomerular endothelial cells. This review discusses the available evidence on the role of interferon-alpha and interferon-beta in viral nephropathies, in kidney diseases triggered by extrarenal infections, in lupus nephritis, and in other kidney disease entities. Finally, we propose areas of research that may help unravel the roles of type I interferons and interferon-related genes in the renal field. Kidney International (2010) 77, 848-854; doi:10.1038/ki.2010.71; published online 17 March 2010

引用

页码：848 / 854

页数：7

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