The Origins of Sexually Transmitted HIV Among Men Who Have Sex with Men

被引：64

作者：

Butler, David M. ^{[1
]}

Delport, Wayne ^{[1
]}

Pond, Sergei L. Kosakovsky ^{[1
]}

Lakdawala, Malcolm K. ^{[1
]}

Cheng, Pok Man ^{[1
]}

Little, Susan J. ^{[1
]}

Richman, Douglas D. ^{[1
,2
]}

Smith, Davey M. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, La Jolla, CA 92093 USA

[2] Vet Adm San Diego Healthcare Syst, San Diego, CA 92161 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2010年 / 2卷 / 18期

基金：

美国国家科学基金会;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; GENETIC ALGORITHM; PRIMARY INFECTION; DRUG-RESISTANCE; TRANSMISSION; TYPE-1; SEMEN; SELECTION; VARIANTS; RISK;

D O I：

10.1126/scitranslmed.3000447

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although it is known that most HIV-1 infections worldwide result from exposure to virus in semen, it has not yet been established whether transmitted strains originate as RNA virions in seminal plasma or as integrated proviral DNA in infected seminal leukocytes. We present phylogenetic evidence that among six transmitting pairs of men who have sex with men, blood plasma virus in the recipient is consistently more closely related to the seminal plasma virus in the source. All sequences were subtype B, and the env C2V3 of transmitted variants tended to have higher mean isoelectric points, contain potential N-linked glycosylation sites, and favor CCR5 co-receptor usage. A statistically robust phylogenetically corrected analysis did not detect genetic signatures reliably associated with transmission, but further investigation of larger samples of transmitting pairs holds promise for determining which structural and genetic features of viral genomes are associated with

引用

页数：7

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