Assembly and plasticity of the glutamatergic postsynaptic specialization

被引：75

作者：

McGee, AW ^{[1
]}

Bredt, DS ^{[1
]}

机构：

[1] Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2003年 / 13卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-4388(03)00008-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glutamate mediates most excitatory synaptic transmission in the brain. Synaptic strength at glutamatergic synapses shows a remarkable degree of use-dependent plasticity and such modifications may represent a physiological correlate to learning and memory. Glutamate receptors and downstream enzymes are organized at synapses by cytoskeletal proteins containing multiple protein-interacting domains. Recent studies demonstrate that these 'scaffolding' proteins within the postsynaptic specialization have the capacity to promote synaptic maturation, influence synapse size, and modulate glutamate receptor function.

引用

页码：111 / 118

页数：8

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