HIV-1 Env-specific cytotoxic T-lymphocyte responses in exposed, uninfected Kenyan sex workers:: a prospective analysis

被引：31

作者：

Kaul, R ^{[1
]}

Rutherford, J

Rowland-Jones, SL

Kimani, J

Onyango, JI

Fowke, K

MacDonald, K

Bwayo, JJ

McMichael, AJ

Plummer, FA

机构：

[1] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya

[2] Univ Toronto, Dept Med, Div Clin Sci, Toronto, ON, Canada

[3] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

[4] John Radcliffe Hosp, Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford, England

来源：

AIDS | 2004年 / 18卷 / 15期

关键词：

D O I：

10.1097/00002030-200410210-00015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prospective significance of HIV-specific cytotoxic T lymphocyte (CTL) responses in highly exposed, persistently seronegative populations is unknown. In 1996-1997 we screened for CTL responses against HIV clade B Env in 39 recently enrolled Kenyan female sex workers, and followed these women prospectively. Annual HIV incidence was 5.8%. CTL were independently associated with age and recent HIV-1 exposure, but were not prospectively associated with protection in a multivariable model that included HIV-1 exposure and duration of sex work.

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页码：2087 / 2089

页数：3

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