Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya.

被引：162

作者：

Hanke, T ^{[1
]}

McMichael, AJ ^{[1
]}

机构：

[1] John Radcliffe Hosp, Inst Mol Med, MRC, Human Immunol Unit, Oxford OX3 9DS, England

来源：

NATURE MEDICINE | 2000年 / 6卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/79626

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using recent advances in biological and medical sciences, a new candidate human immunodeficiency virus (HIV) vaccine has been developed and tailor-designed for a phase III clinical trial in Kenya. It has two components, DNA and MVA (an attenuated poxvirus), used in a prime-boost vaccination protocol. Both of these vaccine vehicles express a common 'chimeric' protein derived from small parts of the HIV genome. The vaccine focuses on the induction of cell-mediated immune responses.

引用

页码：951 / 955

页数：5

共 45 条

[1] Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen [J].

Allen, TM ;

Vogel, TU ;

Fuller, DH ;

Mothé, BR ;

Steffen, S ;

Boyson, JE ;

Shipley, T ;

Fuller, J ;

Hanke, T ;

Sette, A ;

Altman, JD ;

Moss, B ;

McMichael, AJ ;

Watkins, DI .

JOURNAL OF IMMUNOLOGY, 2000, 164 (09) :4968-4978

[2] Cross-clade human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte responses in HIV-infected Zambians [J].

Betts, MR ;

Krowka, J ;

Santamaria, C ;

Balsamo, K ;

Gao, F ;

Mulundu, G ;

Luo, CW ;

NGandu, N ;

Sheppard, H ;

Hahn, BH ;

Allen, S ;

Frelinger, JA .

JOURNAL OF VIROLOGY, 1997, 71 (11) :8908-8911

[3] A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure [J].

Binley, JM ;

Sanders, RW ;

Clas, B ;

Schuelke, N ;

Master, A ;

Guo, Y ;

Kajumo, F ;

Anselma, DJ ;

Maddon, PJ ;

Olson, WC ;

Moore, JP .

JOURNAL OF VIROLOGY, 2000, 74 (02) :627-643

[4] The influence of wildfire on aqueous-extractable soil solutes in forested and wet meadow ecosystems along the eastern front of the Sierra-Nevada range, California [J].

Blank, RR ;

Zamudio, DC .

INTERNATIONAL JOURNAL OF WILDLAND FIRE, 1998, 8 (02) :79-85

[5] Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine [J].

Cafaro, A ;

Caputo, A ;

Fracasso, C ;

Maggiorella, MT ;

Goletti, D ;

Baroncelli, S ;

Pace, M ;

Sernicola, L ;

Koanga-Mogtomo, ML ;

Betti, M ;

Borsetti, A ;

Belli, R ;

Åkerblom, L ;

Corrias, F ;

Buttò, S ;

Heeney, J ;

Verani, P ;

Titti, F ;

Ensoli, B .

NATURE MEDICINE, 1999, 5 (06) :643-650

[6]

CALLAHAN LF, 1995, ARTHRIT CARE RES, V8, P1

[7] HIV-SPECIFIC T-HELPER ACTIVITY IN SERONEGATIVE HEALTH-CARE WORKERS EXPOSED TO CONTAMINATED BLOOD [J].

CLERICI, M ;

LEVIN, JM ;

KESSLER, HA ;

HARRIS, A ;

BERZOFSKY, JA ;

LANDAY, AL ;

SHEARER, GM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (01) :42-46

[8] Distinct recognition of non-clade B human immunodeficiency virus type 1 epitopes by cytotoxic T lymphocytes generated from donors infected in Africa [J].

Dorrell, L ;

Dong, T ;

Ogg, GS ;

Lister, S ;

McAdam, S ;

Rostron, T ;

Conlon, C ;

McMichael, AJ ;

Rowland-Jones, SL .

JOURNAL OF VIROLOGY, 1999, 73 (02) :1708-1714

[9] Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers [J].

Ferrari, G ;

Humphrey, W ;

McElrath, MJ ;

Excler, JL ;

Duliege, AM ;

Clements, ML ;

Corey, LC ;

Bolognesi, DP ;

Weinhold, KJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (04) :1396-1401

[10] Multiepitopic B- and T-cell responses induced in humans by a human immunodeficiency virus type 1 lipopeptide vaccine [J].

Gahéry-Ségard, H ;

Pialoux, G ;

Charmeteau, B ;

Sermet, S ;

Poncelet, H ;

Raux, M ;

Tartar, A ;

Lévy, JP ;

Gras-Masse, H ;

Guillet, JG .

JOURNAL OF VIROLOGY, 2000, 74 (04) :1694-1703

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