Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner

被引：265

作者：

Tamura, Masaru

Tanaka, Shigekazu

Fujii, Tomoaki

Aoki, Aya

Komiyama, Hiromitu

Ezawa, Kiyoshi

Sumiyama, Kenta

Sagai, Tomoko

Shiroishi, Toshibiko

机构：

[1] Natl Inst Genet, Genet Strains Res Ctr, Mammalian Genet Lab, Mishima, Shizuoka 4110845, Japan

[2] Grad Univ Adv Studies, Sch Life Sci, Dept Genet, Mishima, Shizuoka 4110845, Japan

[3] Juntendo Univ, Shizuoka Hosp, Sch Med, Dept Neurosurg, Shizuoka 4102295, Japan

[4] Juntendo Univ, Sch Med, Dept Coloproctol Surg, Bunkyo Ku, Tokyo 1138421, Japan

[5] Natl Inst Genet, Div Populat Genet, Mishima, Shizuoka 4110845, Japan

来源：

GENOMICS | 2007年 / 89卷 / 05期

关键词：

Gsdm family; Dfna5; Dfnb59 (pejvakin); gastrointestinal tract; epithelium; gene duplication; evolution;

D O I：

10.1016/j.ygeno.2007.01.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Gasdermin (Gsdm) was originally identified as a candidate causative gene for several mouse skin mutants. Several Gsdm-related genes sharing a protein domain with DFNA5, the causative gene of human nonsyndromic hearing loss, have been found in the mouse and human genomes, and this group is referred to as the DFNA5-Gasdermin domain family. However, our current comparative genomic analysis identified several novel motifs distinct from the previously reported domain in the Gsdm-related genes. We also identified three new Gsdm genes clustered on mouse chromosome 15. We named these genes collectively the Gsdm family. Extensive expression analysis revealed exclusive expression of Gsdm family genes in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Further database searching revealed the presence of other related genes with a similar N-terminal motif. These results suggest that the Gsdm family and related genes have evolved divergent epithelial expression profiles. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：618 / 629

页数：12

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