Noninvasive detection of counterfeited ampoules of dexamethasone using NIR with confirmation by HPLC-DAD-MS and CE-UV methods

被引：27

作者：

Rodionova, Oxana ^{[1
]}

Pomerantsev, Alexey ^{[1
,2
]}

Houmoller, Lars ^{[3
]}

Shpak, Alexey ^{[4
]}

Shpigun, Oleg ^{[4
]}

机构：

[1] RAS, Inst Chem Phys, Moscow 119991, Russia

[2] State S Res & Testing Site RAS, Soci 354000, Russia

[3] Arla Foods Amba, DK-6920 Videbaek, Denmark

[4] Moscow MV Lomonosov State Univ, Moscow 119991, Russia

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2010年 / 397卷 / 05期

关键词：

High quality forgeries; PCA; NIR; HPLC-DAD-MS; CE-UV; NEAR-INFRARED SPECTROSCOPY; TABLETS;

D O I：

10.1007/s00216-010-3711-y

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Application of near-infrared (NIR) measurements together with chemometric data processing is widely used for counterfeit drug detection. The most difficult counterfeits to detect are the "high quality fakes", which have the proper composition but are produced in violation of technological regulations by underground manufacturers. This study uses such forgeries and addresses important issues. The first is the possibility of applying the NIR/chemometric approach to the detection of injectable formulations of drugs (in this case dexamethasone), which are aqueous solutions with low concentration of active ingredients, directly in the closed ampoules. The second issue is the comparison of NIR/chemometric conclusions with detailed chemical analysis.

引用

页码：1927 / 1935

页数：9

共 11 条

[1]

[Anonymous], 2006, COMB COUNT DRUGS CON

[2]

NIR spectroscopy: a rapid-response analytical tool [J].