The beginning of the end: Death signaling in early involution

被引：54

作者：

Baxter, Fiona O. ^{[1
]}

Neoh, Kevin ^{[1
]}

Tevendale, Maxine C. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2007年 / 12卷 / 01期

关键词：

early involution; NF-kappa B; PI(3)K; Stat3; TGF beta;

D O I：

10.1007/s10911-007-9033-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mammary gland involution occurs in two distinct phases: an early, reversible phase, involving extensive apoptosis of the secretory alveolar epithelium without major changes in gland architecture, and a later, irreversible phase, involving remodelling of the gland to its pre-pregnancy state. Multiple signalling pathways are known to be important during early involution, however the precise triggers remain elusive. This review summarizes the roles of a number of key pathways (NF-kappa B, PI(3)K, Stat3, and TGF beta) in the first phase of involution.

引用

页码：3 / 13

页数：11

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