Convenient syntheses of (3S,5S)-carbapenam-3-carboxylates and their biosynthetic relevance

被引：18

作者：

Bycroft, BW ^{[1
]}

Chhabra, SR ^{[1
]}

Kellam, B ^{[1
]}

Smith, P ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharmaceut Sci, Nottingham NG7 2RD, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 05期

关键词：

carbapenam-3-carboxylate; biosynthesis; absolute configuration; beta-lactam; tris(1,3-dihydro-2-benzoxazolin-3-yl)phosphine; oxide;

D O I：

10.1016/S0040-4039(02)02731-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from readily available glutamate derivatives, facile stereoselective syntheses of (3S,5S)-carbapenam-3-carboxylates have been developed. Their significance in confirming the absolute configuration of the natural material is discussed. (C) 2003 Published by Elsevier Science Ltd.

引用

页码：973 / 976

页数：4

共 15 条

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