Bacterial production of carbapenems and clavams:: evolution of β-lactam antibiotic pathways

被引：28

作者：

McGowan, SJ

Bycroft, BW

Salmond, GPC

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

[2] Univ Nottingham, Dept Pharmaceut Sci, Nottingham NG7 2RD, England

来源：

TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0966-842X(98)01251-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Research into two of the four classes of naturally produced beta-lactams - the clavams and carbapenems - has started to throw light upon their biochemical pathways and underlying genetics. Interesting similarities between these two classes, from their joint discovery to an apparently common beta-lactam ring-forming enzyme, are now being revealed.

引用

收藏

页码：203 / 208

页数：6

相关论文

共 43 条

[1] STRUCTURE AND ABSOLUTE-CONFIGURATION OF THIENAMYCIN [J].

ALBERSSCHONBERG, G ;

ARISON, BH ;

HENSENS, OD ;

HIRSHFIELD, J ;

HOOGSTEEN, K ;

KACZKA, EA ;

RHODES, RE ;

KAHAN, JS ;

KAHAN, FM ;

RATCLIFFE, RW ;

WALTON, E ;

RUSWINKLE, LJ ;

MORIN, RB ;

CHRISTENSEN, BG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (20) :6491-6499

[2] Chemistry and biosynthesis of clavulanic acid and other clavams [J].

Baggaley, KH ;

Brown, AG ;

Schofield, CJ .

NATURAL PRODUCT REPORTS, 1997, 14 (04) :309-333

[3] ENZYMES OF VALCLAVAM BIOSYNTHESIS [J].

BALDWIN, JE ;

FUJISHIMA, Y ;

GOH, KC ;

SCHOFIELD, CJ .

TETRAHEDRON LETTERS, 1994, 35 (17) :2783-2786

[4] NATURALLY-OCCURRING BETA-LACTAMASE INHIBITORS WITH ANTIBACTERIAL ACTIVITY [J].

BROWN, AG ;

BUTTERWORTH, D ;

COLE, M ;

HANSCOMB, G ;

HOOD, JD ;

READING, C .

JOURNAL OF ANTIBIOTICS, 1976, 29 (06) :668-669

[5] MUTANTS OF STREPTOMYCES-CATTLEYA DEFECTIVE IN THE SYNTHESIS OF A FACTOR REQUIRED FOR THIENAMYCIN PRODUCTION [J].

BUCHAN, T ;

ROACH, C ;

RUBY, C ;

TAYLOR, D ;

PREISIG, C ;

REEVES, C .

JOURNAL OF ANTIBIOTICS, 1994, 47 (09) :992-1000

[6] THE ISOLATION AND CHARACTERIZATION OF (3R,5R)-CARBAPENAM-3-CARBOXYLIC AND (3S,5R)-CARBAPENAM-3-CARBOXYLIC ACID FROM SERRATIA AND ERWINIA SPECIES AND THEIR PUTATIVE BIOSYNTHETIC ROLE [J].

BYCROFT, BW ;

MASLEN, C ;

BOX, SJ ;

BROWN, AG ;

TYLER, JW .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (21) :1623-1625

[7] THE BIOSYNTHETIC IMPLICATIONS OF ACETATE AND GLUTAMATE INCORPORATION INTO (3R,5R)-CARBAPENAM-3-CARBOXYLIC ACID AND (5R)-CARBAPEN-2-EM-3-CARBOXYLIC ACID BY SERRATIA SP [J].

BYCROFT, BW ;

MASLEN, C ;

BOX, SJ ;

BROWN, A ;

TYLER, JW .

JOURNAL OF ANTIBIOTICS, 1988, 41 (09) :1231-1242

[8]

Coulton S, 1996, Prog Med Chem, V33, P99, DOI 10.1016/S0079-6468(08)70304-7

[9] Probable role of clavaminic acid as the terminal intermediate in the common pathway to clavulanic acid and the antipodal clavam metabolites [J].

Egan, LA ;

Busby, RW ;

IwataReuyl, D ;

Townsend, CA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (10) :2348-2355

[10] 2 NOVEL ARGININE DERIVATIVES FROM A MUTANT OF STREPTOMYCES-CLAVULIGERUS [J].

ELSON, SW ;

BAGGALEY, KH ;

FULSTON, M ;

NICHOLSON, NH ;

TYLER, JW ;

EDWARDS, J ;

HOLMS, H ;

HAMILTON, I ;

MOUSDALE, DM .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (15) :1211-1212

← 1 2 3 4 5 →