Bacterial production of carbapenems and clavams:: evolution of β-lactam antibiotic pathways

被引：28

作者：

McGowan, SJ

Bycroft, BW

Salmond, GPC

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England

[2] Univ Nottingham, Dept Pharmaceut Sci, Nottingham NG7 2RD, England

来源：

TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0966-842X(98)01251-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Research into two of the four classes of naturally produced beta-lactams - the clavams and carbapenems - has started to throw light upon their biochemical pathways and underlying genetics. Interesting similarities between these two classes, from their joint discovery to an apparently common beta-lactam ring-forming enzyme, are now being revealed.

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收藏

页码：203 / 208

页数：6

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