THE IDENTIFICATION OF 3 NEW BIOSYNTHETIC INTERMEDIATES AND ONE FURTHER BIOSYNTHETIC ENZYME IN THE CLAVULANIC ACID PATHWAY

被引：56

作者：

ELSON, SW ^{[1
]}

BAGGALEY, KH ^{[1
]}

DAVISON, M ^{[1
]}

FULSTON, M ^{[1
]}

NICHOLSON, NH ^{[1
]}

RISBRIDGER, GD ^{[1
]}

TYLER, JW ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT, BETCHWORTH RH3 7AJ, SURREY, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 15期

关键词：

D O I：

10.1039/c39930001212

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Labelling experiments are described that identify three new compounds, N2-(2-carboxyethyl)arginine, 5-guanidino-(2-oxoazetidin-1-yl)pentanoic acid, and 3-hydroxy-5-guanidino-2-(2-oxoazetidin-1-yl)pentanoic acid as biosynthetic precursors of proclavaminic acid and hence clavulanic acid in Streptomyces clavuligerus ATCC 27064 and a new amidino hydrolase, which hydrolyses 3-hydroxy-5-guanidino-2-(2-oxoazetidin-1-yl)pentanoic acid to proclavaminic acid has been characterised.

引用

页码：1212 / 1214

页数：3

共 20 条

[1] STUDIES ON THE BIOSYNTHESIS OF CLAVULANIC ACID .5. ABSOLUTE STEREOCHEMISTRY OF PROCLAVAMINIC ACID, THE MONOCYCLIC BIOSYNTHETIC PRECURSOR OF CLAVULANIC ACID
BAGGALEY, KH
ELSON, SW
NICHOLSON, NH
SIME, JT
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (06): : 1521 - 1533
[2] A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID
BALDWIN, JE
LLOYD, MD
WHASON, B
SCHOFIELD, CJ
ELSON, SW
BAGGALEY, KH
NICHOLSON, NH
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (06) : 500 - 502
[3] EARL A, UNPUB COMMUNICATION
[4] THE ROLES OF CLAVAMINIC ACID AND PROCLAVAMINIC ACID IN CLAVULANIC ACID BIOSYNTHESIS
ELSON, SW
BAGGALEY, KH
GILLETT, J
HOLLAND, S
NICHOLSON, NH
SIME, JT
WORONIECKI, SR
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (22) : 1739 - 1740
[5] THE IDENTIFICATION OF 3 NEW BIOSYNTHETIC INTERMEDIATES AND ONE FURTHER BIOSYNTHETIC ENZYME IN THE CLAVULANIC ACID PATHWAY
ELSON, SW
BAGGALEY, KH
DAVISON, M
FULSTON, M
NICHOLSON, NH
RISBRIDGER, GD
TYLER, JW
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (15) : 1212 - 1214
[6] ELSON SW, 1981, RECENT ADV CHEM BETA, P142
[7] ELSON SW, UNPUB
[8] CLEAVAGE OF ESTERS USING CARBONATES AND BICARBONATES OF ALKALI-METALS - SYNTHESIS OF THYMOPENTIN
KAESTLE, KL
ANWER, MK
AUDHYA, TK
GOLDSTEIN, G
[J]. TETRAHEDRON LETTERS, 1991, 32 (03) : 327 - 330
[9] MONOSUBSTITUTED GUANIDINES FROM PRIMARY AMINES AND AMINOIMINOMETHANESULFONIC ACID
KIM, KY
LIN, YT
MOSHER, HS
[J]. TETRAHEDRON LETTERS, 1988, 29 (26) : 3183 - 3186
[10] KUCHTA RD, 1985, J BIOL CHEM, V260, P3181

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