ENZYMES OF VALCLAVAM BIOSYNTHESIS

被引：12

作者：

BALDWIN, JE ^{[1
]}

FUJISHIMA, Y ^{[1
]}

GOH, KC ^{[1
]}

SCHOFIELD, CJ ^{[1
]}

机构：

[1] OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)77032-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two enzymes of the clavulanic acid pathway, clavaminic acid synthase (CAS) and proclavaminic acid amidino hydrolase (PAH), were detected in mycelia of Streptomyces antibioticus ssp antibioticus Tu 1718. These enzymes are presumably involved in the biosynthesis of valclavam, indicating a shared biosynthetic pathway between clavulanic acid and valclavam.

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页码：2783 / 2786

页数：4

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