The pre-B-cell receptor

被引：58

作者：

Martensson, Inga-Lill ^{[1
]}

Keenan, Rebecca A. ^{[1
]}

Licence, Steve ^{[1
]}

机构：

[1] Babraham Inst, Lab Lymphocyte Signaling & Dev, Cambridge CB2 4AT, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2007年 / 19卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/j.coi.2007.02.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pre-B-cell receptor (pre-BCR) is composed of two immunoglobulin mu heavy chains and two surrogate light chains, which associate with the signaling molecules Ig alpha and Ig beta (Ig alpha/beta). The production of a functional pre-BCR is the first checkpoint in the current model of B-cell development. The pre-BCR mediates signals resulting in heavy chain allelic exclusion, down-regulation of the recombination machinery, developmental progression, V-H repertoire selection, proliferation and down-regulation of the surrogate light chain genes. Recent studies suggest that some of these processes could take place at an earlier stage in B-cell development than previously thought, and might not result from signals mediated by the pre-BCR.

引用

页码：137 / 142

页数：6

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