Ianthesines A-D, four novel dibromotyrosine-derived metabolites from a marine sponge, Ianthella sp.

被引：43

作者：

Okamoto, Y ^{[1
]}

Ojika, M ^{[1
]}

Kato, S ^{[1
]}

Sakagami, Y ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan

来源：

TETRAHEDRON | 2000年 / 56卷 / 32期

基金：

日本学术振兴会;

关键词：

amino acids and derivatives; enzyme inhibitors; marine metabolites; natural products;

D O I：

10.1016/S0040-4020(00)00544-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel dibromotyrosine-derived metabolites, ianthesines A, B, C, and D, were isolated from an Australian marine sponge of the genus Ianthella sp. Their structures were elucidated using chemical and spectroscopic techniques. Ianthesines A, B, and D were derived from two dibromotyrosines. Ianthesine C is a tetramer possessing eight bromine atoms and its molecular weight is 1606. Ianthesines B-D showed Na,K-ATPase inhibitory activity in the range of 50-440 mu M, whereas ianthesine A is inactive. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5813 / 5818

页数：6

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