General enantioselective synthesis of butyrolactone natural products via ruthenium-SYNPHOS®-catalyzed hydrogenation reactions

被引：50

作者：

Blanc, Delphine ^{[1
]}

Madec, Jonathan ^{[1
]}

Popowyck, Florence ^{[1
]}

Ayad, Tahar ^{[1
]}

Phansavath, Phannarath ^{[1
]}

Ratovelomanana-Vidal, Virginie ^{[1
]}

Genet, Jean-Pierre ^{[1
]}

机构：

[1] Coll France, CNRS UMR 7573, Lab Synth Select Organ & Prod Nat, F-75231 Paris 05, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 06期

关键词：

asymmetric catalysis; atropisomerism; hydrogenation; ruthenium; total synthesis;

D O I：

10.1002/adsc.200600504

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Enantioselective syntheses of several paraconic acids have been achieved using catalyzed asymmetric, hydrogenation of beta-keto esters with SYNPHOS (R) as a ligand. This strategy allowed the short synthesis of biologically active (-)-methyleno-lactocin 1, (-)-protolichesterinic acid 2, (-)-phaseoconic acids have been achieved using linic acid 3 and (+)-roccellaric acid 4.

引用

页码：943 / 950

页数：8

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