Conformational toolbox of oxazaborolidine catalysts in the enantioselective reduction of α-bromo-ketone for the synthesis of (R,R)-formoterol

被引:41
作者
Hett, R [1 ]
Senanayake, CH [1 ]
Wald, SA [1 ]
机构
[1] Sepracor Inc, Chem Res & Dev, Marlborough, MA 01752 USA
关键词
D O I
10.1016/S0040-4039(98)00137-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Several conformationally constrained oxazaborolidine catalysts have been evaluated in the reduction of ketone 1. Readily accessible (1R, 2S)1-amino-2-tetralol (B-H) derived oxazaborolidine catalyst (6b) proves to be the most effective and practical catalyst in the reduction of bromo-ketone 1 (96% ee). (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1705 / 1708
页数:4
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