Conformational toolbox of oxazaborolidine catalysts in the enantioselective reduction of α-bromo-ketone for the synthesis of (R,R)-formoterol

被引：41

作者：

Hett, R ^{[1
]}

Senanayake, CH ^{[1
]}

Wald, SA ^{[1
]}

机构：

[1] Sepracor Inc, Chem Res & Dev, Marlborough, MA 01752 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(98)00137-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several conformationally constrained oxazaborolidine catalysts have been evaluated in the reduction of ketone 1. Readily accessible (1R, 2S)1-amino-2-tetralol (B-H) derived oxazaborolidine catalyst (6b) proves to be the most effective and practical catalyst in the reduction of bromo-ketone 1 (96% ee). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1705 / 1708

页数：4

共 29 条

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