Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs

被引：32

作者：

Toba, Tetsuya

Murata, Kenji

Nakanishi, Kyoko

Takahashi, Bitoku

Takemoto, Naohiro

Akabane, Minako

Nakatsuka, Takashi

Imajo, Seiichi

Yamamura, Takashi

Miyake, Sachiko

Annoura, Hirokazu

机构：

[1] Biomedical Research Laboratories, Daiichi Asubio Pharma Co., Ltd

[2] National Institute of Neuroscience, National Center for Neuroscience and Psychiatry

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 10期

关键词：

OCH; Th2; cytokine; non-linear phytosphingosine analogs;

D O I：

10.1016/j.bmcl.2007.02.081

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogs of immunomodulatory glycolipid OCH (2) were prepared and minimum structure requirement to exhibit equivalent profiles was disclosed. Analogs bearing non-linear hydrocarbon chain in the phytosphingosine moiety (18, 19) were shown for the first time to possess comparable cytokine inducing profile to 2. Molecular modeling of 2/hCD1d complex based on the crystal structure of alpha-GalCer (1)/hCDld complex is also described. (c) 2007 Elsevier Ltd. All rights reserved.

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页码：2781 / 2784

页数：4

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